![\"\"](\"https:\/\/internacional.umh.es\/files\/2022\/04\/Sa\u0301ez_Perez_Cuchillo-foto-300x194.jpg\")
<\/a>The research team of Roc\u00edo P\u00e9rez, Javier S\u00e1ez and Inmaculada Cuchillo.<\/p><\/div><\/p>\n
\u201cCharacterization of Extracellular Vesicles in Blood for the Refinement of Early Biomarkers and the Progression of Alzheimer\u2019s Disease,\u201d a cooperation project from the Miguel Hern\u00e1ndez University of Elche (UMH), strives to examine extracellular vesicles from blood samples from the largest and most homogenous group of familial Alzheimer\u2019s disease known, from the Antioquia region in Colombia, and to identify possible biomarkers for the diagnosis and progression of this disease.<\/p>\n
Javier S\u00e1ez Valero, a UMH Professor of Biochemistry & Molecular Biology and researcher from the Institute of Neurosciences, is coordinating this project. Other project participants include Inmaculada Cuchillo Ib\u00e1\u00f1ez, a researcher from the Institute of Neurosciences and CIBERNED (The Network Center for Biomedical Research in Neurodegenerative Diseases); and Roc\u00edo P\u00e9rez Gonz\u00e1lez, a specialist in extracellular vesicles, under contract by ISABIAL (Alicante Institute for Biomedical and Health Research). Also collaborating in the project are Gloria Patricia Cardona G\u00f3mez and Rafael Andr\u00e9s Posada Duque, both from the University of Antioquia.<\/p>\n
Alzheimer\u2019s disease is the most prevalent type of dementia in aging populations, it is still an incurable pathology, and it affects the quality of life in patients and their families. The clinical manifestations that precede the stage of dementia are not useful for determining rapid therapeutic intervention, so this is why having biomarkers for better diagnosis and biological monitoring are necessary.<\/p>\n
The project\u2019s research team has begun isolating extracellular vesicles with two distinct techniques and has begun characterizing their protein content. Extracellular vesicles are characterized as they contain proteins and microRNA from the cells of origin, and thus permit proteins that form part of brain cells in living patients to be analyzed in blood. This way, if accessible protocols can be developed for isolating blood samples from vesicles and enriching those of a brain origin, it would be possible to develop biomarkers of diagnostic utility and of value in monitoring both the evolution of the disease as well as the possible effectiveness of therapies. This represents an advance in understanding Alzheimer\u2019s and other brain pathologies, and makes clinical intervention more effective.<\/p>\n
This project was selected in the call for international research projects from a 2020 agreement to fulfill the Sustainable Development Goals from the United Nations 2030 Agenda, which was announced by the UMH and funded by the Generalitat Valenciana. The development of this project contributes to fulfillment of SDG 3, \u201cEnsure healthy lives and promote well-being for all at all ages.\u201d<\/p>\n
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The research team of Roc\u00edo P\u00e9rez, Javier S\u00e1ez and Inmaculada Cuchillo.
\n\u201cCharacterization of Extracellular Vesicles in Blood for the Refinement of Early Biomarkers and the Progression of Alzheimer\u2019s Disease,\u201d a cooperation project from the Miguel Hern\u00e1ndez University of Elche (UMH), strives to examine extracellular vesicles from blood samples from the largest and most homogenous group of […]<\/p>\n","protected":false},"author":5216,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"_links_to":"","_links_to_target":""},"categories":[20504,46075,20486,296002,20482],"tags":[95],"yoast_head":"\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\t\n\t\n\t\n